Reverse Engineering the Human Immune System

Our Research

Our lab is focused on harnessing the power of single cell and computational biology to study and model how human immune cells sense and respond to their environment. We start by innovating new experimental and computational methods that enable the profiling and analysis of immune cells at unprecedented resolution, precision, and scale. We use these tools to systematically dissect immune circuits in health and disease. In healthy donors, we measure the natural variability in immune response and model how genetics and biological rhythms tune immune circuits to affect a person’s risk for disease or response to treatment. In patients with infectious disease, autoimmunity, neurodegeneration and cancer, we search for common failure modes in immune circuits and identify novel targets for therapeutic intervention. Building on this work, the lab is initiating new efforts to translate our insights into design specifications that can aid the development of personalized medicines and engineered immune circuits for future therapeutic strategies. 


Tldr: we build tech, write code, study immunology, and develop medicine.

Our Partners


Our People

We are a highly dynamic and interdisciplinary team with diverse expertise in functional genomics, computational biology, human genetics, and immunology.


Media highlights of Ye Lab's research.
Your Immune System Could Turn COVID-19 Deadly
We Need Volunteers To Improve Our Understanding of the Human Immune System
‘AutoImmunoprofiler’ Builds on Success in Cancer Research to Advance Treatments for Autoimmune Diseases

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Recent Lab News

December 2020

Elizabeth McCarthy has been awarded the NIH F30 Fellowship

November 2020

Cody Mowery has been awarded the NIH F30 Fellowship

November 2019

Graice Gordon has been awarded the NIH F31 Fellowship